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National Institute of Mental Health, Addiction Research Center, P. It is a centrally acting skeletal "muscle relaxant ", and is said to be particularly effective in releasing decerebrate rigidity [ 1] .

Hospital, Lexington, Kentucky Carisoprodol (N-isopropyl-2-methyl-2-propyl-l,3-propanediol dicarbamate) is closely related to meprobamate in chemical structure [ 1] .

Throughout the test, patients and aides independently completed a chronic dosage opiate questionnaire [ 7] at 7 p.m. Clinical toxicity was evaluated by observations and by laboratory tests made prior to drug administration and repeated at bi-weekly intervals, when carisoprodol was administered, as follows: routine analyses of urine, red and white blood cell counts, hemoglobin content, hematocrit and liver function tests (thymol turbidity cephalin flocculation and evidence of bilirubin in the urine).

An electrocardiogram was made on each patient while receiving placebos, and again after a high dosage of carisoprodol had been reached--i.e., 4,200 or 4,800 mg daily.

Since both compounds represent new structural departures for analgesics, experiments were carried out at the Addiction Research Center to ascertain if either possessed mor-phinedike addictive qualities in man.

That it may affect the central perception of certain forms of pain is suggested by behaviour of a dog subjected to painful stimulation of an extremity.Significant differences (P (0.05) as compared to a placebo are shown by an asterisk.The total dosage of each drug substituted to suppress symptoms of abstinence from morphine is shown in milligrammes. - Carisoprodol partially but significantly (P 0.05) suppressed symptoms of abstinence (figure 1), as tabulated by the hourly point score of Himmelsbach [ 8] .All patients initially received placebo capsules for 12 days, 4 received carisoprodol for 18 days and one for 54 days.Carisoprodol was withdrawn abruptly and replaced by identically appearing capsules.




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